1537. Multicenter Study with Therapeutic Drug Monitoring (TDM) of Voriconazole (VRCZ) in Japanese Patients
نویسندگان
چکیده
منابع مشابه
Voriconazole therapeutic drug monitoring.
We report on 28 patients who underwent voriconazole monitoring because of disease progression or toxicity. A relationship (P<0.025) between disease progression and drug concentration was detected. Favorable responses were observed in 10/10 patients with concentrations above 2.05 microg/ml, while disease progressed in 44% (n=18) of patients with concentrations below 2.05 microg/ml.
متن کاملVoriconazole Pharmacokinetics and Therapeutic Drug Monitoring : A Multi - Center Study
Voriconazole Pharmacokinetics and Therapeutic Drug Monitoring: A Multi-Center Study 1 2 Michael J Dolton, John E Ray, Sharon C-A Chen, Kingsley Ng, Lisa G Pont, Andrew J 3 McLachlan 4 5 1 Faculty of Pharmacy, University of Sydney, Camperdown, Australia 6 2 Clinical Pharmacology & Toxicology, SydPath, St Vincent’s Hospital, Darlinghurst, 7 Australia 8 3 Centre for Infectious Diseases & Microbiol...
متن کاملSuccessful management of voriconazole-associated hyponatremia with therapeutic drug monitoring.
Voriconazole is a broad-spectrum triazole antifungal agent and the first-choice therapy for invasive aspergillosis (IA) (1). Although voriconazole is generally well tolerated, anecdotal case reports have described unexpected severe adverse events related to voriconazole, such as hyponatremia, which potentially could result in death (2–4). We report a case of successful voriconazole treatment of...
متن کاملTherapeutic drug monitoring (TDM) of atazanavir in pregnancy
Methods In this prospective, open labelled study, pregnant HIVpositive women received ATV/r as part of their routine pre-natal care. Demographic and clinical data were collected, and ATV plasma concentrations [ATV] were determined in the first (T1) and/or second (T2) and/or third (T3) trimester using HPLC-MS/MS (LLQ = 0.05 μg/mL). Postpartum (PP) sampling was performed where applicable. Antepar...
متن کاملPractice guidelines for therapeutic drug monitoring of voriconazole: a consensus review of the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring
Voriconazole (VRCZ) is a triazole antifungal developed for the treatment of fungal infectious disease and is available for both oral and intravenous administration. It has potent activity against a broad spectrum of clinically significant pathogens, including Aspergillus, Candida, Cryptococcus, Fusarium, and Scedosporium [1]. VRCZ has a nonlinear pharmacokinetic profile with wide interand intra...
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ژورنال
عنوان ژورنال: Open Forum Infectious Diseases
سال: 2019
ISSN: 2328-8957
DOI: 10.1093/ofid/ofz360.1401